Prednisolone is a hormonal drug that is chemically analogous to hydrocortisone synthesized by the adrenal glands. At the same time, the active component is 4 times stronger than the natural one. The main purpose is the relief of allergic reactions, suppression of inflammatory processes, prevention of anaphylactic shock.
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Indications for use
The remedy is indicated for use in various diseases. The directions of use depend on the form of release. So, a solution for injection and pills are used in the case of such disorders and diseases:
• multiple sclerosis;
• lung cancer;
• minor chorea;
• allergic diseases of different nature;
• acute alveolitis;
• bronchial asthma;
• hypocorticism (primary and secondary);
• dysfunction of the adrenal cortex, including congenital;
• autoimmune diseases;
• excess calcium associated with cancer;
• nephrotic syndrome;
• in case of rejection of transplanted organs after surgery;
• inflammation of the digestive organs, etc.
Contraindications to use
There is a fairly large list of contraindications to the use of the drug. The most extensive list is related to the ban on the use of solution for injections and pills. They should not be used in the presence of such pathologies as:
• individual intolerance;
• tuberculosis, mycosis and other infectious pathologies;
• myocardial infarction (if it was recently transferred);
• immunodeficiency, including HIV-related;
• diseases of the digestive system (including ulcerative lesions, diverticulitis);
• the period after the vaccine (you need to wait at least 2 months before and 2 weeks after);
• severe renal or hepatic insufficiency;
• thyroid disorders;
• diabetes mellitus;
• acute psychosis;
• systemic osteoporosis;
• severe obesity (starting from stage 3);
• complications after removal of a foreign body from the eye and much more
Prednisone in pills: instructions
Pills begin to be taken with a dosage of 20-30 mg once a day. For maintenance therapy, a dosage of 5 to 10 mg is used. In some cases, for example, if a nephrotic syndrome is diagnosed, the dosage is increased in consultation with the doctor.
Children are given no more than 2 mg per kilogram of weight. The daily dosage is divided into 4-6 times, for maintenance therapy, no more than 0.6 mg per 1 kg of body weight is given.
Since the complications of Prednisolone therapy depend on the dose and duration of treatment, in each case, based on the analysis of the risk-benefit ratio, a decision is made on the need for such treatment, as well as the duration of treatment and the frequency of administration.
The lowest dose of Prednisolone should be used, providing sufficient therapeutic effect; if necessary, dose reduction should be carried out gradually.
Due to the risk of arrhythmia, the use of Prednisolone in high doses should be carried out in a hospital equipped with the necessary equipment (electrocardiograph, defibrillator).
With long-term treatment, the patient should undergo regular examination (chest X-ray, glucose concentration in blood plasma 2 hours after eating, general urine analysis, blood pressure, body weight control, preferably X-ray or endoscopic examination if there is a history of gastrointestinal ulcers).
The growth and development of children on long-term therapy with Prednisone should be carefully monitored. Growth retardation can be observed in children receiving long-term daily therapy divided into several doses. The daily use of prednisone for a long time in children is possible only for absolute indications. The use of the drug every other day can reduce the risk of developing this side effect or avoid it altogether.
Prednisolone should also be administered with great caution to patients with confirmed or suspected parasitic infections such as strongyloidosis.